Abstract
The effects of ionizing radiation upon erythroid proliferation and development were studied in 14-day and 17-day fetal mouse liver erythroid cells. Globin synthesis was utilized as a marker of an erythroid specific event. Within 2 hr after irradiation at 500 rad, (/sup 3/H)uridine incorporation in 14-day erythroid cells was decreased; within 4 hr after irradiation (/sup 3/H)leucine incorporation into protein was significantly inhibited. Column analyses confirmed that globin synthesis was inhibited. There was no additive effect between irradiation and actinomycin. Cells from the 17th day of gestation had decreased sensitivity to ionizing radiations. The hypothesis is suggested that when the erythroid mass is rapidly expanding and globin synthesis is tightly linked to mRNA production, irradiation exerts profound and rapid effects which are not noted when the erythroid compartment is more stable.
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