Abstract
Sedimentation of the DNA from control rabbit retinal cells revealed a major peak at 580 Svedberg units. Following a single injection of 20 mg/kg of sodium iodoacetate (IAA), the percent of DNA in this control peak showed a rapid decline which persisted for about 3 hr. From 5–10 hr after injection, the percent of DNA in the control peak increased after which a secondary, slower decline occurred which levelled off at about 20 hr and then persisted for at least 5 days. Electron microscopy demonstrated changes in the chromatin material of the visual cells during the period of investigation. Electroretinograms were depressed shortly after injection but were completely recovered 6 hr later and remained normal throughout the experimental period. It is suggested that IAA induces an initial damage to the DNA which is capable of being repaired but that a concomitant slower toxic action results in irreversible damage to a portion of the DNA. The residual damage to the DNA may be related to the “latent” effect of IAA toxicity observed by other investigators.
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