Abstract
The effects of intravenous anesthetics on ischemia-reperfusion injury (IRI) have been investigated in both animals and clinical studies. The protective effects and the dosages of the intravenous anesthetics on IRI were discussed in this paper. The prevention of the tissue injury after the IRI was demonstrated with intravenous anesthetics in some studies. In the future, the studies should be focused on the dosage of the anesthetics related to diminishing the tissue injuries. Further studies might be required in order to investigate the effects of the anesthetics on molecular levels.
Highlights
Ischemia-reperfusion injury (IRI) can be resulted from many factors such as the release of free oxygen radicals and consecutive lipid peroxidation, cell death by apoptosis or necrosis, inflammatory cytokines, and damage to the microvasculature [1, 2]
Thorough understanding of the pathophysiology of liver IRI may yield novel therapeutic strategies to reduce IRI and lead to improved clinical outcomes [3]. Both experimental and clinical studies focusing on the reduction of IRI report that tissue injury may be prevented through the use of anesthetic agents or anesthesia methods
A continuous infusion of dexmedetomidine (1 μg/kg for 10 minutes, followed by 0.5 μg/kg h−1) was used until the end of surgery, whereas the control group received an equivalent volume of saline. Their results suggest that dexmedetomidine may offer advantages by inhibiting lipid peroxidation in the case of anticipated ischemia-reperfusion injury, which would occur in upper-extremity surgery requiring tourniquet application [19]
Summary
Ischemia-reperfusion injury (IRI) can be resulted from many factors such as the release of free oxygen radicals and consecutive lipid peroxidation, cell death by apoptosis or necrosis, inflammatory cytokines, and damage to the microvasculature [1, 2]. The results of the study indicated that remifentanil postconditioning protected the heart from ischemia-reperfusion injury to a similar extent as of ischemic postconditioning This protection involves κ and δ but not μ opioid receptor activation [13]. The cardioprotective effects of IV-administered fentanyl using a model of myocardial ischemia-reperfusion injury associated with pharmacologically induced central sympathetic over activity were investigated. A continuous infusion of dexmedetomidine (1 μg/kg for 10 minutes, followed by 0.5 μg/kg h−1) was used until the end of surgery, whereas the control group received an equivalent volume of saline Their results suggest that dexmedetomidine may offer advantages by inhibiting lipid peroxidation in the case of anticipated ischemia-reperfusion injury, which would occur in upper-extremity surgery requiring tourniquet application [19]. Hypertension following the administration of high-dose dexmedetomidine is associated with cerebral hypoperfusion and the exacerbation of ischemic brain injury, possibly through alpha-2-induced cerebral vasoconstriction [21]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
