The effect of intravenous administration of gadolinium contrast medium on diffusion-weighted MR of breast

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Objective To evaluate the effect of intravenous Gd-DTPA on DWI of breast. Methods DWI was performed before and after Gd-DTPA injection on 25 patients with breast cancer confirmed by core or fine-needle aspiration biopsy. The signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and ADC values were measured on DWI when b = 0 and 1000 s/mm2 were selected. A paired t-test and non-parametric test were used to compare the differences between SNR, CNR and ADC values before and after enhancement in breast cancer and normal breast. Results There were no significant differences between the SNR(34. 56 ± 11.34 and 33.60 ± 14. 34 for cancer, 9. 88 ± 3.16 and 10. 42 ± 4. 18 for normal breast)and CNR( 24. 16 ± 9. 05 and 22. 26 ± 10. 05 ) before and after administration of contrast medium in breast cancer and normal breast, and no significant differences between the ADC values before and after administration of contrast medium in breast cancer [(0.96±0. 13) × 10-3 vs (0.95±0. 14) × 10-3 mm2/s] and normal breast[(1.90±0.47) × 10-3 vs (1.91±0.61) × 10-3 mm2/s], either (P =0.20 and 0.97). Conclusion It is possible to repeat DWI acquisition after administration of contrast medium in breast MRI. Key words: Breast; Diffusion magnetic resonance imaging; Contrast media