The effect of intraoperative magnesium sulfate and ketamine infusion on post-operative pain in open gynecological surgeries

Abstract

Background:besides an opioid analgesic, Multimodal analgesia using a non-opioid analgesic, in atrial to decrease opioid use and toincrease postoperative pain control. Objectives:To compare the effect of intra-operative infusion of ketamine and magnesium sulphate in open gynecological surgeries on post-operative pain, total morphine consumption, post-operative nausea, and vomiting inQena university hospitals. Patients and method(s):A prospective study. Conducted in Qena university hospital, South Valley University, Qena, Egypt. The study was conducted on fifty patients (ASA I or II) scheduled for open gynecological surgeries under general anesthesia: group A: Ketamine (0.2 mg/ kg) bolus than the continuous supply of ketamine (0.05 mg/kg/h), group B: Magnesium sulphate (50mg/ kg) bolus and followed by continuous infusion of magnesium sulfate(10mg/kg /h). Result(s): the visual analogue scale was found to be significantly higher in group B compared to group A in 2, 4, and 8 hrs time intervals. The mean opioid (Morphine/Pethidine) consumption doses over 24h were lower in group A compared to group B. There is no significant difference regarding adverse events between the two studied groups. Conclusion: Intraoperative magnesium sulfate and ketamine infusionin patients exposed to gynecological surgeries with general anesthesia could and decreased the post-operative opioid requirement. Ketamine showed a significant preemptive analgesic effect compared to MgSO4 at 2 and 8 h postoperatively. VAS was significantly lowered in Ketamine than MgSO4.