Abstract
Objective To evaluate the impact of intraoperative administration of S-adenosy-methionine on early remnant liver function and regeneration after left lobe resection. Methods 60 cases undergoing left lobe resection were randomly divided into two groups (30 cases in each group). While post-op therapies were the same. Patients in the experimental group received intraoperatively intravenous injection of S-adenosy-methionine 1 000 mg. Postoperatively the two groups were injected with S-adenosy-methionine 1 000 mg/d daily for successive 5 days. Results Liver function injury was markedly alleviated in experimental group after hepatectomy, Level of ALT, AST, TBiL, IBiL index were lower than the control group, the difference was statistically significant (P<0.05); the LRR and the expression of IL-22 was significantly higher than the control group and the difference was statistically significant (P<0.05), which indicated improved liver regeneration. Conclusion The intraoperative pretreatment of S-adenosy-methionine can reduce the damage of remnant liver function, promote the restoration of remnant liver function and liver regeneration. Key words: Hepatectomy; Liver regeneration; Liver function test
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.