Abstract
Intracerebroventricular (i.c.v.) injection of 3-mercaptopropionic acid (3-MP, 250 μg/10 μl) elicited an elevation of blood pressure in a dose-dependent manner in anaesthetized rats. This elevation of blood pressure could be blocked by treatment with amino-oxyacetic acid (AOAA, 25 mg/kg, i.p.) 5 h prior to the i.c.v. injection of 3-MP. Given intraperitoneally (i.p.), 3-MP (75 mg/kg) had no effect on blood pressure of heart rate. I.c.v. injection of 3-MP produced a selective decrease in GABA content in the diencephalon and mesencephalon, whereas i.p. injection of 3-MP caused a decrease in GABA content in all regions of brain, including telencephalon, diencephalon, mesencephalon, pons and medulla. The results suggest that the elevation of blood pressure induced by i.c.v. injection of 3-MP may be the result of a selective depletion of GABA in diencephalon and/or mesencephalon. Decreases in GABA content in brain regions other than diencephalon and mesencephalon may lead to an opposite effect in modulating blood pressure.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
