Abstract
The effect of intraduodenal fat infusion on histamine-stimulated gastric acid secretion was studied in dogs with Heidenhain pouches; there was a significant inhibition of acid output but there was no significant change in acid concentration. This suggests that intraduodenal fat infusion inhibits gastric water secretion to the same extent as it inhibits gastric acid secretion. Histamine caused a marked initial increase in pepsin output (“washout” effect), followed by a secondary sustained increase. The intraduodenal administration of fat abolished the secondary increase in pepsin secretion. The depressant effect of intraduodenal fat on gastric acid and pepsin secretion may play a significant role in the prevention of peptic ulceration.
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