The Effect of Interval Training with Selenium Consumption on Gene Expression of Caspase- 3 and Cyclin-D in Liver Tissue of Cadmium-Exposed Rats

Abstract

Background: Cadmium is one of the heaviest metals in the natural environment that can increase DNA damage in liver cells, nevertheless, it has been reported that physical activity and nutrition can improve the damage of DNA in liver cells. Objectives: The aim of the present research was to review the effect of interval training and selenium on cyclin-D and caspase-3 gene expression in liver tissue of cadmium-exposed rats. Methods: In the present experimental research, 30 rats were divided to six groups of (1) control, (2) sham, (3) cadmium, (4) selenium consumption with cadmium, (5) interval training with cadmium consumption, and (6) interval training with selenium and cadmium consumption. For eight weeks, groups three to six received 2 mg/kg of cadmium per day; groups four and six consumed 0.23 mg/kg of selenium per day and groups five and six performed three sessions of selected interval training per week. Results: Cadmium consumption significantly increased cyclin-D and caspase-3 (P = 0.001); selenium consumption and interval training had a significant effect on decreasing caspase-3 and cyclin-D levels (P = 0.001); concurrent interval training with selenium consumption had interactive effects on the increase of cyclin-D (P = 0.001). However, there was no interactive effect on the reduction of caspase-3 (P = 0.75). Conclusions: It seems that interval training with selenium consumption has interactive effects on hepatocyte apoptotic factors in rats exposed to cadmium.