Abstract
The distribution space of galactose has been determined in normal and diabetic eviscerated–nephrectomized rats and in their hearts, gastrocnemius muscles, and adipose tissues at different levels of plasma glucose, by a method not dependent on the assumption of non-utilization of galactose. Insulin was found to increase the galactose space in the whole carcass, the heart, and in muscle, but not in adipose tissue in both normal and diabetic preparations. This increase after the injection of insulin was found to be smaller in diabetic preparations than in normal ones. NaHCO3partially restored insulin sensitivity in diabetic preparations. There was a negative correlation between the plasma glucose level and the galactose space in the whole carcass and in the heart, and a similar relation in muscle, in the insulin-injected rats. Dinitrophenol and puromycin did not interfere with the effect of insulin on the expansion of the galactose space in the carcass, heart, or muscle.
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