Abstract
PERMANENT DIABETES has been produced in the dog by means of the injection of suitable extracts of the anterior pituitary by a number of investigators (1–4). However, as yet no one has been able to obtain similar results in the intact rat. Permanent diabetes has been established in this species by the injection of anterior pituitary extracts only after partial pancreatectomy (5). This resistance of the rat to anterior pituitary extract has attracted considerable attention. Anselmino, Herold, and Hoffmann (6) reported that the administration of an aqueous extract of an acetonedried pituitary preparation to normal rats resulted in a substantial increase in the number and size of the islets of Langerhans in a few days. Hoffmann and Anselmino (7) showed that these histological changes were associated with a fall in blood sugar and attributed these effects to a pancreatropic action of the pituitary extract. In 1937 Richardson and Young
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