Abstract
Low-intensity laser irradiation exerts effects on various biological objects and is currently exploited in various branches of medicine. From a practical point of view, irradiation in the near-infrared range seems most attractive since it has the highest penetration characteristics for human tissues. In the present work, we studied the effects of 835 nm infrared low-intensity laser irradiation on two melanoma cell lines, Mel IL and MeWo, in culture. The data that we obtained indicate that low-intensity infrared irradiation impacts the growth rate of Mel IL and MeWo melanoma cell lines and that the response dynamics of the two cell lines are similar, in spite of certain quantitative differences. Stimulation of cell growth occurs within a relatively narrow range of low doses (about 0.17 J/cm2). With significantly higher doses, deceleration of growth occurs instead. Рге-treatment of cells with low-dose radiation, however, protects them from the negative influence of higher doses. The protective action of low doses develops gradually, within about 10–30 min, and persists for at least 3 h. Рге-irradiation of cells also widens the range of stimulatory action with low-dose radiation. A theoretical model that explains the dynamics of cellular responses to various irradiation doses has been proposed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
