Abstract
Coronavirus disease 2019 (COVID-19) pandemic is rapidly developing worldwide with a high mortality rate. In this meta-analysis study, the effect of influenza vaccination on the prevention of COVID-19 and its consequences in patients were investigated. The systematic search for this study was performed from November 2019 to 25 November 2020, in the databases of Medline, PubMed, Scopus, Web of Science, Embase, Ebsco, Cochrane and medRxiv. Search terms used included COVID-19, coronavirus, SARS-CoV-2, covid, influenza, flu, grippe and vaccine. The present study examined the association between influenza vaccination and COVID-19 including COVID-19 infection, mortality, hospitalisation and intensive care unit (ICU) admission. Finally, the pooled estimates for different outcomes were calculated by the software for statistics and data science (STATA) version 15 and I2 was used to determine the heterogeneity. By analysing the data of articles, the pooled estimates of these data indicated that influenza vaccination could lower probability of COVID-19 infection up to 24% (OR = 0.77; 95% CI: 0.65, 0.91), of death up to 32% (OR = 0.68; 95% CI: 0.42, 1.11), of the hospitalisation up to 25% (OR = 0.75; 95% CI: 0.46; 1.23) and of admission to ICU up to 29% (OR = 0.71; 95% CI: 0.40, 1.27). Influenza vaccination can help decrease the COVID-19 infection and reduce hospitalisation and the need for ICU and mortality rates.
Highlights
The newly found coronavirus has caused the coronavirus disease 2019 (COVID-19)
All studies included in this metaanalysis were evaluated for the relationship between receiving the influenza vaccine and the probability of getting infected by COVID-19
The pooled odds ratio (OR) of these data indicated that influenza vaccination reduced the rate of COVID-19 to 24% (OR = 0.77; 95% CI: 0.65, 0.91) (Figure 2) [14–17, 19, 25–27], where the pooled estimates of adjusted and nonadjusted studies showed a significant difference (P = 0.020) indicating 12% and 64% reduction, respectively
Summary
In December 2019, the first case of the COVID-19 infection was reported in Wuhan, China [1]. This virus was a new strain of coronavirus which rapidly spread all around the world [2]. It is estimated that 8 out of 10 patients manifest mild symptoms of COVID-19 and remaining two cases become severely critical [4]. If this trend continues and no intervention is applied, it may affect the communities for several years and impose a heavy burden both on people and economy of countries, especially those with poor health systems [5]
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