Abstract

PURPOSE: Chronic obstructive pulmonary disease (COPD) is a smoking related inflammatory lung disease. Tumor necrosis factor-alpha is thought to play an important role in the induction and maintenance of this inflammation. No effective anti-inflammatory agents are currently available to reduce airway inflammation in COPD. Aim: To evaluate the anti-inflammatory effect of the anti-TNF drug infliximab in patients with mild COPD.

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