Abstract
1. 1. In the isolated rabbit arteries, the effects of intravenous cyclosporin A preparation (Sandimmun) and its solvent (Cremophor-EL) on acetylcholine-induced endothelium-dependent relaxation were investigated in the absence and presence of indomethacin (10 −5M), a cyclooxygenase inibitor. 2. 2. The effect of indomethacin on the drug- and solvent-induced contraction of superior mesenteric artery was also evaluated. 3. 3. The inhibitory effects of cyclosporin and the solvent on endothelium-dependent relaxations were decreased by indomethacin. The direct contractions produced by the drug and the solvent in rabbit mesenteric artery were inhibited by indomethacin.
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