The effect of increased femoral anteversion on the morphological and trabecular microarchitectural changes in the trochlea in an immature rabbit

Abstract

Increased femoral anteversion (FA) has been recently demonstrated as one risk factor for recurrent patellar dislocation (RPD). However, it has been still unclear whether the increase of FA can result in patellar dislocation, and subsequent morphological and trabecular microarchitectural changes in the trochlea has not been investigated. Forty knees from 20 rabbits at 3 months of age were included. The right knees underwent surgery with internal rotation of distal femur to increase FA, with the left knees acting as internal controls. The surgical knees were called operated group, and non-operated knees were control group. Micro-CT scans for distal femur were acquired after 4 months of surgery. In the operated group, a boss located proximal to the entrance of the groove was formed. The central trochlear height was significantly greater, sulcus angle was significantly greater, both lateral and medial trochlear slope were significantly lower, and boss height was significantly greater in comparison to the control group. Regarding the microarchitectural changes, the trabecular thickness were increased by 67.5% at the groove, 33.0% and 29.5%, at the medial and lateral femoral condyle, and trabecular number were decreased by 37.8% and 26.5% at the groove and medial femoral condyle. This study provided a novel animal model of trochlea dysplasia by femoral rotational osteotomy and increased FA. These changes were associated with the load redistribution in the patellofemoral joint after the increase of FA.