Abstract
Since tobacco smoke contains 1.5–4.5% carbon monoxide cigarette smoking induces a rise in the blood CO-hemoglobin concentration with a subsequent decrease in the O2-capacity and a simultaneous increase in the hemoglobin O2-affinity. Both effects cause a restriction of respiratory gas exchange. Aim of the present study was to investigate the influence of tobacco smoking during pregnancy on the O2-affinity and the CO2-binding of maternal blood. Using the derived results, a model describing the blood O2 dissociation curve for the conditions of increased concentrations of CO-hemoglobin and of 2,3-DPG was developed. In addition, maternal to fetal oxygen transfer at elevated CO-hemoglobin fractions in maternal blood was analysed.
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