Abstract
Rats were kept in a low-pressure chamber /simulated altitude of 18,300 ft/ for six hours, to induce hypoxia. The LDH activities in the sera and in the heart muscle extracts were measured. The total LDH activity and the activity of heat stable isozyme in serum elevated significantly in the experimental group. The ratio of the activity of heat stable isozyme related to the total LDH activity has not changed significantly. The LDH activity in the heart muscle extract has slightly decreased in the experimental group but this change was not significant. It has been suggested that as a result of a general cellular damage LDH liberates from the different organs into the sera of rats exposed to hypoxia.
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