The Effect of Hypoparathyroidism on the Aging Skeleton

Abstract

Serum concentrations of parathyroid hormone are frequently increased in elderly subjects. How much this increase may contribute to the development of osteoporosis in such subjects is unknown. Long-standing hypoparathyroidism has been reported to be accompanied by an increase in skeletal density. In seven consecutive women, aged 40 to 83 years, with hypoparathyroidism of at least 18 years duration, the mineral density in the lumbar vertebrae was measured by quantitative computed tomography (QCT) and dual photon absorptiometry (DPA). In these subjects, the bone mineral density by dual photon absorptiometry was 1.4 to 6.2 standard deviations above mean values for age-matched normal women. However, the mineral density of vertebral trabecular bone as determined by quantitative computed tomography was only slightly increased above values reported for normal women. The differences between the values determined by dual photon absorptiometry and quantitative computed tomography indicate that most of the increase in mineral density was a reflection of increased cortical bone. Roentgenograms of the metacarpals did not reveal consistent differences between normals and the hypoparathyroid subjects. These findings suggest the possibility that control of parathyroid function might be of value in treating osteoporotic patients.