The Effect of Hydroxyurea and Mitomycin-C to Prevent Postoperative Adhesion and Fibrosis After Hang-Back Recession in Rabbits

Abstract

To investigate a way to prevent postoperative adhesion and fibrosis after hang-back recession surgery, an animal study was carried out to evaluate the effect of mitomycin-C (MMC) and hydroxyurea (HU) on this procedure. A prospective, masked-observer, controlled study was performed in New Zealand rabbits. Bilateral hang-back recession of superior and inferior rectus muscle was performed and MMC and HU were applied 5 minutes between muscle-sclera and muscle-conjunctiva with a sponge (groups I and II), whereas other eyes of these rabbits were reserved as control group (group III). In this study, the degree of postoperative adhesion, fibrosis, and vascularization of conjunctiva were recorded and compared. In groups I and II, the records of postoperative adhesion and fibrosis were found to be significantly lower than in the control group. The new insertion line was more regular in groups I and II. Histopathological examination of these muscles revealed decreased fibrosis of perimuscular connective tissue in eye groups I and II. This article suggests that HU and MMC can help to reduce postoperative adhesion, fibrosis, and vascularization of conjunctiva in rabbits that underwent hang-back recession surgery.