Abstract
Previous research has indicated that fluid choice is an important component of the resuscitation of the critically-ill patient. Synthetic hydroxyethyl starches (HES) may remain within the intravascular space compared to crystalloid solutions, yet they have also been associated with acute kidney injury. Data comparing HES and crystalloid solutions in anesthesia is incomplete. The goal of this study was to evaluate the effect of utilizing HES on adverse patient outcomes in vascular surgery patients at a Canadian academic hospital.
Highlights
Previous research has indicated that fluid choice is an important component of the resuscitation of the critically-ill patient
Synthetic hydroxyethyl starches (HES) may remain within the intravascular space compared to crystalloid solutions, yet they have been associated with acute kidney injury
Receiving HES solutions was associated with a greater post-operative hemodialysis requirement (OR = 19.53, CI: 1.54, 247.0), inotrope requirement (OR = 2.74, CI: 1.48, 5.08), ventilator requirement (OR = 8.50, CI: 5.40, 13.40), and intensive care unit (ICU) admission (OR = 9.81, CI: 6.51, 14.77)
Summary
Previous research has indicated that fluid choice is an important component of the resuscitation of the critically-ill patient. Synthetic hydroxyethyl starches (HES) may remain within the intravascular space compared to crystalloid solutions, yet they have been associated with acute kidney injury. Data comparing HES and crystalloid solutions in anesthesia is incomplete. The goal of this study was to evaluate the effect of utilizing HES on adverse patient outcomes in vascular surgery patients at a Canadian academic hospital
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