Abstract
The effects of various grades of polyvinylpyrrolidone (PVP), sodium carboxymethyl-cellulose (SCMC), acid and alkaline gelatins and hydroxypropylmethylcellulose (HPMC) on the electrophoretic mobility of polystyrene latex, and particles of the drugs, nystatin and sulphadimidine, have been examined. In all cases, particle mobility was influenced by the adsorbed polymer molecules with the observed effect being dependent on polymer type, grade and concentration. The non-ionic polymer, PVP, resulted in an appreciable decrease in particle mobility, the effect being greater for the higher molecular weight fractions. However, with the anionic polymer, SCMC, the mobility of particles was controlled by the ionization of the polymer carboxylic groups. The effect of adsorbed gelatin on particle mobility was dependent upon the ionization of the amino acid groups and thus enabled the isoelectric point of the gelatins to be determined from pH-particle mobility plots. HPMC adsorption resulted in a low negative mobility which was independent of PH.
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