Abstract
The research relevance is determined by the deterioration of the environment associated with atmospheric air pollution with sulfur—containing compounds. There are no research data on age—related and specific features of thymus tissue reactions to chronic sour gas intoxication and the dynamics of free radical oxidation processes caused by stress. Besides, in most works devoted to studying the thymus, the description of its anatomy is not based on age and variant morphology. This fact may affect the objective assessment of the research results obtained during experimental studies of this organ. The purpose of this article is to investigate the rhythmic activity of protein synthesis and peculiarities of free-radical processes in rat thymus tissue in postnatal ontogenesis under chronic intoxication. The chronobiological and biochemical research methods allowed me to assess age—related peculiarities of thymus tissue ultradian rhythms under normal conditions and in chronic intoxication with sulfur—containing natural gas. The identified fluctuations in the levels of total protein, albumin, and globulin can be characterized as ultradian rhythms with periods from 20 to 30 min. Experimental data showed that the resistance of thymus tissue decreases with age, and the antioxidant system is depleted in conditions of chronic intoxication. The research is significant for the development of methods for correcting adverse effects in conditions of intoxication.
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