THE EFFECT OF HYDRATION AND PROSTAGLANDIN E1 FOR RENAL INSUFFICIENCY IN ARTERIOSCLEROSIS OBLITERANS

Abstract

The effect of hydration for preventing from renal dysfunction after major angiographies was studied in patients with arteriosclerosis obliterance, especially those associated with impaired renal function. Five protocols of hydration (On condition that 1000 ml of fluid transfusion were administrated on the day of angiography in all cases, group A: 500 ml/day, for more than 3 days before angiography, group B: no other fluid transfusion, group C: 500 ml/day, for each 5 days before and after angiography, group D: 500 ml/day, for 5 days after angiography, group E: Lipo-prostaglandin E1, 10μg/body, was injected just before aortography fromthe catheter in suprarenal aorta)were compaired with each other to establish the most effective hydration. Compairing creatinine clearance (Ccr) on the 7th day after angiography with that of preangiography, Ccr values were reduced by 3.7±18.3%, 10.9±23.9% and 15.0±16.3% in group A, B and D respectively while Ccrs were improved by 8.0±11.2%, and 4.6±11.4% in Group C, and E.Transfusion of 500 ml extracellular fluid/day for each 5 days before and after angiography or administration of Lipo-prostaglandin E1 just before angiography should be performed for preexisting renal insufficient patients (Ccr<50 ml/min) of ASO. If both of them are performed, the incidence of acute renal dysfunction after major angiography will decrease remarkably.