Abstract
Purpose: The purpose of this study was to investigate the transplantation results of human amniotic membrane (HAM), epidermal cells, or marrow mesenchymal stem cel ls (MSCs) in healing a skin defect. Materials and Methods: Defects (full-thickness) in rabbits were treated with HAM alone (group A), HAM injected with cultivated epidermal cells (group B), HAM injecte d with cultivated MSCs (group C), or Vaseline gauze (group D). Tissue granulation, regeneration, re-epithelization and healing time were measured. Defects and healed area were calculated 2 weeks after surgery. Results: The mean healing area was 67.5%, 81.7%, 83.2% and 49.5% in each group, with all treatment groups significantly different than group D (p＜0.01), and groups B and C compared higher than group A (p＜0.05). The healing time of groups A, B, and C was 5.7 to 6.4 days faster than that of group D (p＜0.01). Histologic analysis showed that the new epidermis covered nearly the whole wound surface in group B and C, and contained granulated tissue with fibroblasts, capillaries, and collagen. Conclusion: HAM grafts injected with cultivated epidermal cells or MSCs promoted healing of skin defects.
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