Abstract
SummaryThe effects of hormones on the in vitro biosynthesis of cholesterol palmitate, oleate, and linoleate by rat liver microsomes from cholesterol and fatty acids was studied. It appears that L-thyroxine and glucagon in general stimulate the synthesis of all three esters. Testosterone increases cholesterol palmitate and oleate formation. Its effect on cholesterol linoleate formation varies, being stimulatory at the highest concentration and inhibitory at the lowest concentration of hormone used. The action of 17 β-estradiol on cholesterol esterification also depended on the concentration of the hormone used. However, cholesterol oleate synthesis was markedly stimulated at all concentrations of 17β-estradiol.
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