The effect of hopanthenic acid on the development of cognitive disorders in patients with a mine blast injury

Abstract

Background. In the conditions of hostilities in Ukraine, the number of victims ofmine- explosive injuries among both the military and the civilian population is increasing. These injuries lead to serious damage to the organs and body systems, as well as to the development of various psychological disorders, such as cognitive disorders. The purpose of this paper is to study and correct cognitive disorders in patients with brain concussion due to a mine-explosive injury, using the calcium salt of hopantenic acid. Materials and Methods. For this, the patients underwent the Montreal scale of cognitive function assessment (MoCA), the short mental status assessment scale (MMSE), word encryption tests, and word recall tests. Results. The study was conducted three times, immediately after the injury, and 14 and 21 days later. In the course of the study, it was found that therapy with the calcium salt of hopantenic acid significantly improved neuropsychological indicators (increase in the total MMSE score) and reduced the patient’s cognitive deficit, improved concentration and short-term memory. Conclusions. Thus, the hopantenic acid effectively reduces cognitive impairment in patients with brain concussion due to a mine-explosive injury and is recommended for the treatment of this group of patients.