Abstract
BackgroundHuman oxoguanine glycosylase 1 (hOGG1) in base excision repair (BER) pathway plays a vital role in DNA repair. Numerous epidemiological studies have evaluated the association between hOGG1 Ser326Cys polymorphism and the risk of cancer. However, the results of these studies on the association remain conflicting. To derive a more precise estimation of the association, we conducted a meta-analysis.Methodology/Principal FindingsA comprehensive search was conducted to identify the eligible studies of hOGG1 Ser326Cys polymorphism and cancer risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. We found that the hOGG1 Ser326Cys polymorphism was significantly associated with overall cancer risk (Cys/Cys vs. Ser/Ser: OR = 1.19, 95%CI = 1.09–1.30, P<0.001; Cys/Cys vs. Cys/Ser+Ser/Ser: OR = 1.16, 95%CI = 1.08–1.26, P<0.001). Moreover, in subgroup analyses by cancer types, the stronger significant association between hOGG1 Ser326Cys polymorphism and lung cancer risk was found (Cys/Cys vs. Ser/Ser: OR = 1.29, 95%CI = 1.16–1.44, P<0.001; Cys/Cys vs. Cys/Ser+Ser/Ser: OR = 1.22, 95%CI = 1.12–1.33, P<0.001). The significant effects of hOGG1 Ser326Cys polymorphism on colorectal, breast, bladder, prostate, esophageal, and gastric cancer were not detected. In addition, in subgroup analyses by ethnicities, we found that the hOGG1 Ser326Cys polymorphism was associated with overall cancer risk in Asians (Cys/Cys vs. Ser/Ser: OR = 1.21, 95%CI = 1.10–1.33, P<0.001).ConclusionsThis meta-analysis showed that hOGG1 326Cys allele might be a low-penetrant risk factor for lung cancer.
Highlights
DNA damage plays a vital role in carcinogenesis [1], which generally occurs through different mechanisms such as by-product of normal cellular metabolism or the result of exposure to biological and environmental mutagens
In case of the studies with the same or overlapping data, we selected the most recent ones with the largest number of subjects. Studies included in this meta-analysis should meet the following criteria: (a) evaluation the association of Human oxoguanine glycosylase 1 (hOGG1) Ser326Cys polymorphism and cancer risk published in English language, (b) use a case-control design, (c) contain available genotype frequency, and (d) the distribution of genotypes in the controls was consistent with Hardy-Weinberg equilibrium (HWE)
The agematched control subjects were used in 42 studies, which were included in subgroup analyses by age. 19 studies, which reported data according to gender, were eligible for subgroup analyses by sex
Summary
DNA damage plays a vital role in carcinogenesis [1], which generally occurs through different mechanisms such as by-product of normal cellular metabolism or the result of exposure to biological and environmental mutagens. DNA damage, if it is not repaired, could lead to apoptosis or mutation, which may cause induction of carcinogenesis [1]. The DNA repair enzyme human oxoguanine glycosylase 1 (hOGG1) is a DNA glycosylase/AP lyase that has been indicated to play an important role in preventing carcinogenesis by repairing oxidative damage to DNA [5]. HOGG1 may play a vital role in maintaining genome integrity and preventing the development of cancer. Human oxoguanine glycosylase 1 (hOGG1) in base excision repair (BER) pathway plays a vital role in DNA repair. To derive a more precise estimation of the association, we conducted a meta-analysis
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