Abstract
The inhibition by BCG of leukocyte migration was abolished by histamine in human donors with a positive tuberculin skin test. This effect was related to two mechanisms: a direct stimulation of polynuclear cell migration by histamine, and the production of a LIF production-inhibiting soluble factor (LIF-PI) by nylon-adherent T lymphocytes with receptors for histamine. This factor was not dialyzable, had a molecular weight below 50,000, and was absorbed on aggregated human immunoglobulins. Cells which produced this factor behaved as suppressors of the in vitro human delayed hypersensitivity reaction.
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