Abstract
Phospholipids, which provide valuable model systems for lipid membranes, display a variety of polymorphic phases, depending on their molecular structure and environmental conditions. High hydrostatic pressure has been used as a physical parameter to study the thermodynamic properties and phase behavior of these systems, and because high pressure is a characteristic feature of certain natural membrane environments. By use of small‐angle neutron scattering (SANS), differential scanning calorimetry (DSC), differential thermal analysis (DTA) and volumetric measurements, the temperature and pressure dependent phase behavior of several phospholipid systems, differing in lipid conformation and headgroup structure, have been studied. Possible biochemical implications of these studies are discussed.
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