Abstract
Objective To explore the optimal time points for deep brain stimulation (DBS) on the treatment of morphine addiction and its possible mechanisms by investigating how high-frequency stimulation (HFS) in bilateral nucleus accumbens (NAc) at different time points influences the addictive behaviors of rats with drug addiction. Methods The rats were randomly divided into extinction stimulation group (n = 20) and postextinction stimulation group (n = 20). Ten rats in the extinction stimulation group were treated using 120 Hz HFS during extinction stage while another 10 rats with pseudostimulation were served as control group. The CPP scores were evaluated at the second day after intervention, with total 9 sections accomplished. The CPP scores were evaluated at the second day of the intervention. In the postextinction stimulation group, 120 Hz HFS was intervened during the postextinction stage in 10 experimental rats and pseudostimulation was performed in 10 control rats. Stimulation was performed for 7 days continuously, and a small dose of morphine was administrated to induce relapse after the postextinction period. Results During the extinction phase, CPP scores after HFS were significantly higher. During the postextinction phase, relapse CPP scores after HFS were dramatically lower. Conclusion HFS of bilateral NAc inhibits the extinction of addictive behavior during the extinction phase, and HFS during the postextinction period suppresses relapse of drug seeking behavior.
Highlights
Drug addiction is considered as an encephalopathy with recurrent attacks manifested with obsessive drug self-intake behaviors, which is characterized by nonmedical, long-term, and repeated increase of drug dosage [1]
Is study initially established the model of conditioned place preference (CPP) induced by morphine in rats, and the high-frequency stimulation (HFS) was delivered to bilateral nucleus accumbens (NAc) at the extinction and postextinction stages, respectively, to observe its effects on the addictive behavior of rats and to explore the mechanisms and optimal time points for the treatment of drug addiction using Deep brain stimulation (DBS)
In the established morphine-induced CPP model, the effects of HFS of bilateral nucleus accumbens on the drug seeking behavior of rats were observed during the extinction phase and postextinction phase. e results showed that HFS inhibits extinction during the extinction stage in morphineinduced CPP in rats
Summary
To explore the optimal time points for deep brain stimulation (DBS) on the treatment of morphine addiction and its possible mechanisms by investigating how high-frequency stimulation (HFS) in bilateral nucleus accumbens (NAc) at different time points influences the addictive behaviors of rats with drug addiction. Ten rats in the extinction stimulation group were treated using 120 Hz HFS during extinction stage while another 10 rats with pseudostimulation were served as control group. E CPP scores were evaluated at the second day after intervention, with total 9 sections accomplished. E CPP scores were evaluated at the second day of the intervention. Stimulation was performed for 7 days continuously, and a small dose of morphine was administrated to induce relapse after the postextinction period. CPP scores after HFS were significantly higher. Relapse CPP scores after HFS were dramatically lower. HFS of bilateral NAc inhibits the extinction of addictive behavior during the extinction phase, and HFS during the postextinction period suppresses relapse of drug seeking behavior
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