The Effect of High Fat Formula Liquid Feeding on the Value of PCO2 and Duration of Use of Respiratory Aids for COVID-19 Patients with Critical Illness

Abstract

Background: In December 2019, WHO announced the outbreak of COVID-19 disease caused by SARSCOV2. COVID-19 is a global pandemic characterized by high morbidity and mortality. SARS-CoV2 with there are many symptoms, about 20-26% of patients with COVID-19 pneumonia become severe or critical, requiring hospitalization for respiratory support. In Indonesia, COVID-19 has been increasing since 2020, and on February 2021, the Covid-19.go.id page had 1.157.837 confirmed cases, 176.291 active cases, 949.990 recovered, and 31.556 death cases. Acute respiratory complications requiring treatment in the intensive care unit are the main cause of high morbidity and mortality in patients with COVID-19. Nutrition therapy has influenced for outcomes of COVID-19 patients. Methods: The primary purpose of this study was to compare the value of PCO2, and duration of use of respiratory support for COVID-19 patients with critical illness. The result compared the COVID-19 patients who had been administered with high lipid formula nutrition (PULMOSOL) and patients who had been administered with standard liquid formula nutrition. The rate of the intervention group that experienced an increase in PCO2 was 55.6%, higher than those who experienced a decrease in PCO2 (50%). Results: Based on the analysis results, there was no difference in the administration of PULMOSOL and standard formula based on PCO2 in the use of ventilators in COVID-19 critically ill patients in Dr. M Djamil Padang General Hospital (p>0.05) with HR = 1.39 (95% CI 1.55-3.55). In patients with increased PCO2, it was found that the intervention group who died was 55.6%, lower compared to the control group (62.5%). The same in patients with decreased pCO2, group the intervention group who died was 50.0%, higher than the control group (40%). Conclusion: Statistical tests demonstrated there was no relationship between the administration of PULMOSOL and the outcome of critically ill COVID-19 (p>0.05). Keywords: Covid-19, critically ill, nutrition, high lipid formula