Abstract
Introduction. Multiple Sclerosis is a chronic inflammatory neurodegenerative disease of large magnitude in the world. Method and Goal. To analyze primary studies associating high dose of vitamin D with the prognosis of patients with multiple sclerosis. Results. 9 studies were selected, including 1022 participants. 630 of them were randomized to vitamin D3 supplementation in high dose, 171 in low-dose and 221 receiving placebo. Conclusion. There is evidence that high dose of Vitamin D3 provide immunomodulatory effects in patients with Multiple Sclerosis, showing improvement in the patients' prognosis.
Highlights
Multiple Sclerosis is a chronic inflammatory neurodegenerative disease of large magnitude in the world
Strategy of election of articles The main question of this RI was based on a question using the PICO strategy: “Does the high dosage of vitamin D3 show improvement in prognosis of patients with Multiple Sclerosis?”
It demonstrated that treatment with high dose of vitamin D3 lowers the proportion of IFN-ɣ and TCD4 +IL-17 and is safe
Summary
Multiple Sclerosis is a chronic inflammatory neurodegenerative disease of large magnitude in the world. In Brazil the prevalence average is 8.69/100,000 inhabitants [2]. The disease provides impact on millions of people around the world and in recent years several studies have been conducted in order to investigate the immunomodulatory effects of vitamin D and its relationship with autoimmune diseases. It is characterized as a chronic inflammatory neurodegenerative disease where environmental and genetic factors, and lifestyle, may Ledjane Neves de Oliveira, Conceição Walsimary Justa Uchoa, Eliane da Silva Grazziano, Regimar Carla Machado.
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