Abstract
The effect of hepatocyte growth factor/scatter factor (HGF/SF) on human hair follicle growth was examined using a serum-free organ culture system. The DNA synthesis in human hair follicles and elongation of the hair shaft were measured subsequent to the follicle isolation and culture at 31 °C in 95% O 2-5% CO 2 for 72 h. Results showed that HGF/SF significantly increased 3H-thymidine ( P < 0.001) incorporation and hair follicle length ( P < 0.05). The effect of HGF/SF was dose-dependent with a maximal stimulation at 10 ng/ml.
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