Abstract
BackgroundSerious injuries accompanied by severe bleeding are life-threatening. Post-traumatic hemorrhage involves the risk of developing coagulopathy. Hemostatic dressings are widely used to minimize bleeding. The application of procoagulants in control of hemorrhage may lead to thrombosis or disseminated intravascular coagulation. The aim of this study was to evaluate the effect of hemostatic dressing prototypes on the porcine coagulation system.ResultsFibrinogen and d-dimer concentrations were significantly higher in the experimental groups where hemostatic dressings were used in comparison with the control group. Considerable differences in antithrombin III activity and thrombin–antithrombin complex concentrations were also observed between groups.ConclusionsThe hemostatic dressing comprising modified seton impregnated with 18.0 g/m2 of procoagulant was most effective in preserving the physiological equilibrium between fibrinogenesis and fibrinolysis.
Highlights
Serious injuries accompanied by severe bleeding are life-threatening
In an emergency setting, damaged vessels are often treated with hemostatic dressings, which are left in the wound site until surgical repair [1]
Group I animals were treated with the OBR/G/S sponge, group II pigs—with OBR/MBT/S impregnated with medium levels of procoagulants (22.9 g/m2), and group III animals—with OBR/MS/S impregnated with medium levels of procoagulants (18.0 g/m2)
Summary
Serious injuries accompanied by severe bleeding are life-threatening. Hemostatic dressings are widely used to minimize bleeding. The aim of this study was to evaluate the effect of hemostatic dressing prototypes on the porcine coagulation system. Serious injuries accompanied by severe bleeding are lifethreatening and pose a significant challenge for physicians and veterinarians participating in rescue actions. Global rescue standards, including Trauma Life Support and Tactical Combat Causality Care, include detailed guidelines for using hemostatic dressings. Hemostatic dressings are widely available on the market and they are entering into mainstream use [2]. They differ in the form of application (powder, sponge, cloth), active ingredient which stimulates the clotting system, time to effective hemostasis and side effects [3]. Posttraumatic increases the risk of coagulopathy in patients who have never been diagnosed with clotting disorders
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