The Effect of Hemodialysis on Cardiac Biomarker Levels

Abstract

Background: According to the United States Renal Data System (USRD), the 2013 Annual Data Report indicates that patients with chronic kidney disease (CKD) have higher rates of congestive heart failure, acute myocardial infraction (MI), and cerebral vascular accidents compared to non-CKD patients. Aim of the Study: This study aimed to investigate the effects of the hemodialysis process on cardiac biomarker levels in hemodialysis patients. Method: A prospective study was carried conducted at Emssalata central hospital's hemodialysis department. The study involved a total of 25 individuals, 15 males and 10 females who were undergoing dialysis. A chemistry analyzer was used to measure the serum troponin I (cTn-I), creatin phosphokinase (CPK), and creatine kinase-MB (CK-MB) iso-enzyme in hemodialysis (HD) patients before and after the dialysis process. Results: The results showed that total CPK, CK-MB, and cTn-I levels had no significant differences in CKD patients' pre and post-dialysis, with (p = 0.989, 0.586, and 0.284) respectively. Hemodialysis patients have none significantly higher CPK, CK-MB and cTn-I ratios after hemodialysis process when compared to the values determined to each marker before hemodialysis process. Conclusion: The dialysis process had no effect on the levels of cardiac biomarkers (CPK, CK-MB, and cTn-I) in hemodialysis patients. The cardiac biomarker in hemodialysis patients appears to be unaffected by age, gender, or dialysis duration