Abstract
Sixteen Helicobacter pylori strains were studied in order to determine their neutrophil chemotactic activity and the association with the presence cagA gene. Neutrophil chemotactic activity was detected by a modified Boyden chamber method and the results were expressed in terms of chemotactic index (CI). The presence of cagA was determined by PCR. Of the 16 strains, eight were cagA + and eight were cagA −. All of the isolated strains showed chemotactic activity. The mean value of CI of the patient group was significantly higher than the negative control ( P<0.01). The mean value of CI of zymosan-activated serum ( P<0.05) and the reference strain H. pylori NCTC 11637 (HP11637) ( P<0.01) was significantly higher than the patient group’s mean value of CI. There were no statistical significance in the CI between cagA + and cagA − strains ( P>0.05). It is concluded that H. pylori attracts neutrophils by chemotaxis, however, there is no association with cagA.
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