Abstract
The copolymerization reaction between N-tert-butylacrylamide (NTBA) and maleic anhydride (MA) inp-dioxane solution at 65°C using 2,2′-azoisobutyronitrile (AIBN) as an initiator in nitrogen atmosphere was carried out. The chemical structure of the obtained copolymers from a wide range of monomer feeds was determined by elemental analysis (content of N for NTBA units), Fourier transform infrared (FTIR), and 1H-NMR spectroscopy. Also, the amounts of MA units in the copolymers were found using the chemical titration method. An observed tendency toward alternating copolymerization at ≤50 mol% NTBA concentration in monomer feed and relatively high activity of NTBA growing radical was explained by H-bond formation between C=O (anhydride) and NH (amide) fragments during chain growth reactions. Intrinsic viscosity and the molecular weights of the synthesized copolymers depend on the type of comonomer and the amount of NTBA units in the copolymers. The synthesized poly(NTBA-MA)s containing a functional amphiphilic group show both temperature and pH sensitivity and can be used for biological proposes as a physiologically active macromolecular system.
Highlights
Copolymer is the most successful and powerful method for effecting a systematic change in polymer [1]
Maleic anhydride cannot be homopolymerized under normal conditions [4] or hardly homopropagates, which means that maleic anhydridemaleic anhydride diads are virtually absent in the polymer chain [5]
This study has investigated the results of the synthesis and characterization of poly(NTBA-co-maleic anhydride (MA))s with different compositions by the radical-initiated solution copolymerization of NTBA and MA in a wide range of monomer ratios as a way to obtain new reactive amphiphilic polymers that are potentially useful as carriers for gene delivery
Summary
Copolymer is the most successful and powerful method for effecting a systematic change in polymer [1]. Many polymers with reactive functional groups are being synthesized, tested, and used for the macromolecular properties and for the properties of functional groups These functional groups provide an approach to a subsequent modification of the polymers for a specific end application [3]. Acrylamide and its derivatives can undergo alternating copolymerization with maleic anhydride under the given conditions [8,9,10,11,12,13,14,15,16,17,18]. MA, which contains two adjacent carboxylic acid groups in anhydride form and reactive carbonyl groups that may be subjected to numerous reactions, was selected for polymerizations with NTBA
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