Abstract
Histamine-induced cutaneous wheal responses were measured in 10 healthy subjects. The effect of the potent H 1 blocker, hydroxyzine HCl, the H 2 blocker, cimetidine, and the two drugs in combination was determined. The H 1 blocker alone produced a mean wheal suppression of 75% (p < 0.001). The H 1 plus H 2 blocker produced 84% suppression. The augmented suppression of H 1 plus H 2 blocker vs H 1 blocker was statistically significant (p < 0.02). The H 2 blocker alone produced suppression that was not statistically significant. The results provide additional evidence that H 2 receptors are present in the human cutaneous microcirculation, and add support to the clinical observation of therapeutic efficacy of H 1 plus H 2 blockers seen in some patients with chronic urticaria.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
