Abstract
Background:�Oxidative stress�and�inflammation�play�an important role in�pathogenesis of�brain aging�and neurodegenerative diseases such as�Alzheimer. Green tea�has been shown to have antioxidant, anti-inflammatory, anticancer, and neuroprotective�activity. Objectives: to determine the effect of green tea extract on�spatial memory function and superoxide dismutase�enzyme activity in mice with D-galactose induced dementiaMethods:�An experimental study using "post test only control group design".�Twenty male�BALB/c Mice aged 6-8�weeks were divided into�4�groups.�Negative control group�(NG)�was induced by subcutaneous injection of�D-galactose�(150�mg/kg BW)�once�daily for�6�weeks.�GT-90, GT-270,�GT-540�were induced by�D-galactose�and orally administered with 90, 270, and 540 mg/kg BW of�green tea extract�once daily for 6 weeks.�The spatial memory functions were assessed using Morris water maze and�SOD enzyme activities�were evaluated using ELISA.�One-way Anova and Kruskal-Wallis were used for statistical analysis.�Results: mean�percentage of latency time in the GT-90�(35.29�(SD=�2.69)%),�GT-270�(35.28 (SD= 2.62)%), and�GT-540�(35.62�(SD=5.05)%)�were�significantly�higher compared to that of NG�(20.38�(SD =�3.21)%), p�<0.05). SOD enzyme activity in the�GT-270�(0.78 (SD = 0.07) U/ml)�was�significantly�higher�compared to that of NG�(0.51 (SD = 0.01) U�ml), p= 0.004).Conclusion:�Green tea extract�may�improve�spatial memory�function�and�the activity of�superoxide dismutase�enzyme in mice�with D-galactose induced�dementia.
Highlights
IntroductionObjective: to determine the effect of green tea extract on spatial memory function and superoxide dismutase enzyme activity in mice with D-galactose induced dementia Methods: An experimental study using “post test only control group design”
Oxidative stress and inflammation play an important role in pathogenesis of brain aging and neurodegenerative diseases such as Alzheimer
D-galactose will change into galactitol that can not be metabolized normally, so it will accumulate in the cells, triggering osmotic stress and free radical formation (Miao et al, 2009; Kumar et al, 2011)
Summary
Objective: to determine the effect of green tea extract on spatial memory function and superoxide dismutase enzyme activity in mice with D-galactose induced dementia Methods: An experimental study using “post test only control group design”. Conclusion: Green tea extract may improve spatial memory function and the activity of superoxide dismutase enzyme in mice with D-galactose induced dementia. Alzheimer’s Disease International (ADI) estimated that in 2015 there were 46.8 million patients with dementia worldwide with 9.9 million of new cases annually (one case every 3 second) (Prince et al, 2015). According to World Alzheimer Report in 2015 dementia cases accounted for 13.1% for disability in subjects above 60 years which is much higher than stroke, musculosceletal, cardiovasculer diseases, dan all type of cancer (Prince et al, 2015)
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