The Effect of Grape Seed Extract Supplementation on Delayed Onset Muscle Soreness (DOMS) in Young Healthy Female Students

Abstract

Background: Delayed onset muscle soreness (DOMS) is a common experience after unusual activities particularly eccentric exercises. The aim of the present study was to investigate the effect of grape seed extract (GSE) on some factors of DOMS on non-athletic female students. Method: Twenty young healthy female students were randomly allocated into two experimental (GSE=10n) and placebo (PLC=10n) groups. T produce DOMS, a forty-five repetition of eccentric elbow curl in three sets was performed. Venous blood samples were obtained before and after supplementation, immediately, 24h, and 48h after exercise for analysis of creatine kinase (CK), lactate dehydrogenase (LDH). The pain was assessed by visual analogue scale (VAS). Results: There was a significant increase in CK activity after exercise compared with before exercise in both groups (P<0.05)‚ but no significant differences between two groups at any time (P>0.05). Furthermore, The VAS scores were significantly lower in GSE compared with PLC group 24h and 48h after exercise (P<0.05). Conclusion: Although GSE supplementation has not been able to affect the CK and LDH activity, it seems that its anti-inflammatory or analgesic effects have been reduced the pain caused by DOMS.