Abstract
Gram negative endotoxin (Salmonella abortus equi) significantly inhibited the ATP dependent calcium uptake of canine myocardial sarcoplasmic reticulum (SR). The degree of inhibition was dependent upon the concentration of the endotoxin and its time of exposure to the SR. Significant inhibition was seen at endotoxin concentrations ranging between 0.024 mg/ml and 0.24 mg/ml. Inhibition, at a dose of 0.24 mg/ml, varied between 10.1 ± 0.1 percent with no preincubation to 61.0 ± 5.0 percent after fifteen minutes of preincubation. The relation between depression of the sarcotubular calcium pump and myocardial depression is discussed.
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