Abstract
Objective: Glycodelin, a glycoprotein specific to the reproductive tract, is known to have multiple functions important for normal reproduction. VEGF is a potent angiogenic factor playing a major role in the proliferation of endothelial cells and neovascularization. Studies have demonstrated that glycodelin increases VEGF levels in immortal ovarian adenocarcinoma cells and may facilitate angiogenesis. We set out to determine if a relationship was also present in ovarian cumulus cells obtained at the time of oocyte retrieval in patients undergoing in vitro fertilization. Patients were divided into 4 groups by diagnosis (normal, poor responders, polycystic ovarian syndrome (PCOS), and endometriosis), and cumulus cell VEGF production was evaluated in response to glycodelin within each group.
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