The Effect of Glutathione versus Co-Enzyme Q10 on Male Infertility Original Study

Abstract

Background: Worldwide, numerous people are affected with the infertility problem. Especially married people find it the most stressful problem that can also cause psychological issues. Glutathione is a naturally produced oxidant that is quite useful to preserve other antioxidants. The level of glutathione varies from person to person. It plays a significant role to enhance the sperm motility pattern. Some men who are suffering from infertility problem because of andrological pathologies, the glutathione can eliminate such issues because of therapeutic effect. Men, who have a lower amount of Q 10 in the seminal fluid, experience the slow motion of the sperms. According to various studies, the increase in the quantity of Q 10 automatically enhances the motility of the sperm.Material and Method: The presented prospective randomized placebo-controlled study was conducted in Saladin province of Samarra city (Iraq) between Jan 2016 to Dec 2018. The study deployed 51 infertile male subjects for the administration of oral glutathione (250mg sachets) for tenure of 6-months. Another group of patients 50 received oral Co-enzyme q 10 (200 mg sachets) for 6 months, a third group received a placebo (sugar sachets) for another 6 months.Results: The results revealed oral glutathione and co-enzyme q 10 as an effective treatment for improving the sperm parameters (motility, morphology, sperm concentration) which were statistically significant except for semen volume where P value was > 0.05. Also, this study showed no statistical significance between the use of glutathione and co-enzyme q 10 as a single agent therapy ( P>0.05 ).Outcomes: From this study, we can conclude that both glutathione and co-enzyme q 10 are effective treatment options for improving sperm motility, morphology and concentration