Abstract
High proliferative activity of tumor cells requires a sufficient amount of energy and plastic substrates, in particular glucose [1]. Intensive consumption of this metabolite by tumor cells leads to its depletion in the intercellular environment and creates an uneven distribution of glucose in the tumor [2-3]. As a result, some cells can survive can adapt to glucose deficiency by reprogramming their metabolism and/or by migrating to the vasculature. Tumor cells that lose adhesive contact, become resistant to anoikis and acquire metastasis potential [4]. The ability to undergo such reprogramming may significantly depend on the characteristics of the deficient microenvironment preceding the transition of tumor cells from an adhesive to a de-adhesive state.
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