Abstract
Glucagon substantially modified the plasma pyruvate and lactate responses to a fructose load in diabetic and non-diabetic human subjects. Addition of glucagon (60 μg. per minute for 30 minutes) at the 60th minute of a fructose infusion was followed by a prompt and complete reversal of the elevation of plasma pyruvate produced by the fructose alone. Lactate concentrations also decreased after glucagon, but the change was much less pronounced, so that the lactate-pyruvate ratio increased. These results appear to indicate that glucagon thwarted hepatic utilization of the carbohydrate load and concomitantly altered intra-hepatic redox potential.
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