The Effect of Ginger Extract (zingiber officinale roscoe) on the Number of Neutrophil Cells, Fibroblast and Epithelialization on Incision Wound

Abstract

The wound healing process consists of three phases, namely the inflammatory phase, proliferation, and maturation. An increase in the number of neutrophil cells and macrophages signifies an inflammatory phase. Fibroblasts and epithelialization indicate a proliferation phase, whereas in the maturation phase is marked by the occurrence of wound healing. Ginger (Zingiber officinale Roscoe) contains active substances, namely triterpenoids, flavonoids and saponins. Flavonoids function as anti-inflammatory. Although it has many benefits, the effect of giving ginger extract to neutrophil cells, fibroblasts, and epithelial thickness in incision wounds has not been studied. The purpose of this study was to determine the effect of ginger extract on the number of neutrophil, fibroblast cells, and epithelialization in incision wounds. The research design used was post test only control group design. Rats were divided into control groups given 1% CMC solvents and the treatment group were given oral ginger extract at a dose of 1 g / kg BW. The tissue was observed on days 1, 5 and 10. Based on the results of the Kruskall Wallis test, the p value was 0,000 with α 0,05, so it can be concluded that the administration of ginger (Zingiber officinale Roscoe) can reduce the number of neutrophil cells, increase the number of fibroblast cells, and increase epithelialization of incisional wounds in white mice (Rattus norvegicus).