Abstract
Background: This study aims to investigate genetic polymorphisms in patients with mechanical heart valve dysfunction. Methods: Between January 1994 and December 2004, a total of 83 patients including 18 patients who were reoperated due to mechanical heart valve dysfunction (group 1), 15 patients with normal functions with lower international normalized ratio (INR) levels who underwent mechanical valve replacement (group 2), and 50 healthy individuals (group 3) were included. Factor V Leiden, prothrombin, interleukin (IL-6), and tumor necrosis factor alpha (TNF-a) polymorphisms were investigated for possible relationships between these factors and mechanical heart valve dysfunction. Results: A significant difference in IL-6 polymorphism was found between group 1 and group 3 (p
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