Abstract
In 1951, Johnson and Grimm (1), reporting on the amino acid requirements of Microsporum fulvum, noted that hydroxyproline inhibited the growth of this organism when added to a basic medium containing 18 other amino acids. Earlier, Robbins and McVeigh (2) and Archibald and Reiss (3) had also noted the inhibitory effect of hydroxyproline on the growth of other dermatophytes under certain conditions. On the other hand, a variety of contaminant nonpathogenic fungi as well as pathogenic fungi causing deep mycoses were not similarly inhibited by this amino acid. Rothman (4), furthermore, pointed out that hydroxyproline is the only amino acid among the amino acids occurring in cell proteins which is not present in keratin of human hair (5) and speculated that possibly the absence of hydroxyproline from keratins is the basis for a reasonable explanation of why pathogenic Hyphomycetes are obligate parasites of keratinized materials and do not enter living cells. Our present study was initiated in order to investigate this ingenious hypothesis.
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