The effect of gel with liposomes contaning encapsulated potassium orotate on skin regeneration processes in animals

Abstract

At the Department of Physiology and Chemistry named after Professor A.A. Sysoev, a wound-healing gel with liposomes containing a compound of iodine with polyvinyl alcohol as an antiseptic component, "Liposomide", was developed and obtained. The gel has antiseptic, antiviral, fungicidal and regenerating effects; it leads to more effective healing of wounds of various etiologies and the formation of a better quality scar compared to other drugs used for these purposes. Liposomes serve as nanocontainers for the transport of drugs (in our case, potassium orotate) into tissue cells; at the same time, the maximum wound healing effect is achieved with a minimum dose of drugs. Liposomes deliver the active substance to the cells, in response to this they synthesize and secrete cytokines - an extensive family of biologically active peptides secreted by various cells of the body: T- and B- lymphocytes, monocytes, macrophages, endotheliocytes, fibroplasts, epithelial cells and many others. With their help, cells interact with each other, as well as with other cells within and outside the immune system. In particular, the cells secrete vascular endothelial growth factor - VEGF - cytokine, which accelerates the processes of tissue regeneration and ensures the growth of blood vessels in them. As a result of laboratory tests of the wound-healing gel "Liplsomid" on models of castration wounds in rats, it was found that the drug has 3-5 times greater regenerating ability than the oflomelid ointment used in the control group of animals. The use of Liposomid gel for the healing of post-gastric wounds in piglets also confirmed its higher efficiency in production conditions compared to the Monclavit -1 preparation used in the control group of animals.